Author: Blatt T; Mundt C; Mummert C; Maksiuk T; Wolber R;
Keyhani R; Schreiner V; Hoppe U; Schachtschabel DO; Stab F
Author affiliation: Paul Gerson Unna Forschungszentrum
Beiersdorf AG, Hamburg.
Publication date & source: 1999.04, Z Gerontol Geriat,
32(2):83-8
Oxidative stress (UV irradiation, free radicals) plays a significant
role in aging. Coenzyme Q10 (CoQ10) and exogenously applied antioxidants
can significantly reduce the formation of oxidative stress with increasing
age. In our in vitro and in vivo experiments concerning the parameters of
ultraweak photon emission (UPE), intracellular thiol status, mitochondrial
membrane potential and cell vitality, we demonstrated a diminished
resistance in keratinocytes of old donors against UV irradiation. This
reduced epidermal resistance against oxidative stressors, i.e. UV
irradiation, can be improved by topical application of CoQ10 and
antioxidants like alpha-glucosylrutin (15). Furthermore, our in vivo
investigations show that wrinkles around the region of the eyes ("crow
feet") could be reduced by long-term application of CoQ10.
